![]() ![]() Moreover, the prompt and frequent reappearance of HCC in the transplanted organ results in severely limited effectiveness ( 3, 4). However, the lack of donor organs makes the number of eligible patients small. In the same context, liver transplantation is another option offered only to early-stage HCC patients. Surgical resection offers a limited treatment option for only about 20% of HCC patients because of several factors, such as tumor size, multifocality and vascular invasion with a recurrence rate of post-surgery as high as 50% ( 2). Further, it is considered the third most lethal cancer worldwide with about 700,000 deaths reported annually ( 1). Hepatocellular carcinoma (HCC) is the commonest primary cancer of the liver representing the fifth and the eighth largest cause of cancer in men and women, respectively. Keywords: Hepatocellular carcinoma (HCC) curcumin taurine IL-10 miR-21 In contrast, a low baseline level of circulating miR-141 was associated with poor prognosis.Ĭonclusions: The combined treatment may be able to increase the OS rate by altering the circulating level of IL-10 and miR-21. At the end of the follow-up period, the median overall survival (OS) rate was found to be 17.00 months with a worse OS in patients with high baseline levels of circulating IL-10 and miR-21 compared to those with low levels. Results: The combined treatment was able to produce a significant decrease in the levels of serum IL-10, and miR-21 while it resulted in a non-significant up-regulation of serum miR-141 expression level. Patients were followed-up for a period of 24 months. The level of IL-10 along with the expression levels of miR-141, and miR-21 were monitored in serum before starting the treatment and after each cycle. Methods: Twenty eligible HCC patients administrated an oral dose of 4 g curcumin, 40 mg piperine, and 500 mg taurine daily for three successive treatment cycles, each was a 30-day. ![]() Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21. Curcumin and taurine showed potent anti-tumor activities in pre-clinical and clinical studies by targeting multiple pathways. Policy of Dealing with Allegations of Research Misconductīackground: Investigating and evaluating possible alternative therapeutic strategies to control hepatocellular carcinoma (HCC) is a critical need because of its high prevalence and being one of the most lethal cancers.Policy of Screening for Plagiarism Process. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |